Refrain:
Prefixes precede and advance the meaning.
Without them there, their sense would be misleading.
So if prefixation is what you're seeking
Disconnect your confusion 'cause I'm intervening.

Prefixes change the meaning of everything
Making charged -- supercharged; lasting -- everlasting...

Refrain

Bicycle, bi-level, bilingual, biplane
That's when you have two of the same...

Refrain

Defuse, disinfect, deforest, disobey
De- and dis- make opposites of what you say...